Polymorphism in the pharmaceutical industry Rolf Hilfiker
Publisher: Wiley-VCH

What is perhaps more exciting, he says, is that “incrementally, this strengthens the evidence that a relatively uncommon polymorphism that lowers LDL substantially through PSCK9 mechanisms translates into differences in IHD.” The pharmaceutical industry is currently looking at PSCK9 inhibition as a target for cardiovascular disease, “and these data certainly support that effort,” he maintains. On the other side of the opinion aisle, PhRMA, the trade association for the pharmaceutical industry, contributed its own hysteria. He points out that pioneer companies, those who first create the pharmaceutical product widely claim that patent claims for novel crystal forms is an important component of their intellectual property position, but that it significantly delays the entry of generic versions of drugs once “There are numerous instances where innovator companies have acquired patents on a particular polymorphic form,” says Vure, “which extend beyond the expiry of basic molecule's patent. The Food and Drug Administration (FDA) is announcing the availability of a guidance for industry entitled ``Regulatory Classification of Pharmaceutical Co-Crystals.'' This guidance provides applicants of new drug Traditionally, solid-state polymorphic forms of an API are classified as either crystalline, amorphous, or solvate and hydrate forms, and applicable regulatory schemes for these solid-state polymorphic forms are well-defined. Comprehensive reference for researchers in the field of cancer pharmacogenomics and clinicians, from both academia and industry; Provides a collection of multi-disciplinary topics; Covers the most important aspects of pharmacogenomics applied to cancer patients. "PhRMA is very disappointed with the Indian Supreme Court's decision to deny a patent on It's not sexy, but the guts of the decision came down to something called crystalline polymorphism--a fairly common phenomenon with solid chemicals. In addition, longer Terahertz spectral features of the drug ranitidine hydrochloride, polymorphic forms I and II. Validates and extends previous findings. A letter on understanding triphasic HCV decline during treatment in the era of IL28B polymorphisms and direct acting antiviral agents via mathematical modeling, published in the Journal of Hepatology. The availability of new molecular approaches to the selection of drug therapy is an emerging need, as the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. GlaxoSmithKline - one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better Read more. [0005] In the literature various polymorphic forms of sertraline hydrochloride have been described. Of Health and published in Gut. In light of current interest of pharmaceutical industry, the polymorphic Form V is of very much importance (WO 00/32551). Thus, in the pharmaceutical industry, terahertz technology can be used to identify particular molecules.